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AWAKE

workman:

magictransistor:

Asa Smith. Celestial Illustrations from Smith’s Illustrated Astronomy. 1851. 

Wood engravings with hand highlighting, written by the principal of Public School No. 12 in New York City with the goal “to present all the distinguishing principles in physical Astronomy with as few words as possible”.

(via trashymommarocks)

The Real Amazon Warriors

The Most Common Jobs For The Rich, Middle Class And Poor

Reality Fiction by Tim Parks

Joyce Schroeder

With a patented treatment for breast-cancer tumors and newly formed company, a University of Arizona researcher is poised to move her research out of the lab and into the clinical setting.

Joyce Schroeder has discovered two proteins that work together to drive triple-negative breast cancer. She’s since developed a drug that has been proven in mice to reduce tumor size and prevent metastasis to other parts of the body.

“The best part of the story is that these proteins only interact in cancer cells, avoid toxicity to the body’s other cells,” said Schroeder, a researcher and professor who works in the UA’s Cancer Biology program.

The Cancer Biology program was founded in 1978 and its primary focus is to gain an understanding of how cancer works at a cellular level, how normal cells turn malignant and how tumor cells grow and spread.

Schroeder says she hopes to move her treatment into the human clinical trial phase within the next year.

“Right now we’re doing the work to prove to the FDA that PMIP is nontoxic before we can move into phase one clinical trials,” she said.

The drug, PMIP —Protein Transduction Domain 4, MUC1 Inhibitory Peptide — blocks the proteins’ ability to bind, shrinking the tumor in size and inhibiting metastasis.

Schroeder and her husband, Todd Caminisch, a professor at the University’s Department of Pharmacology and Toxicology, partnered with investor Robert Sarver to create Arizona Cancer Therapeutics in 2013.

Since its formation, the company has also received a grant from the National Cancer Institute to help further development of PMIP.

Once they begin the clinical trial, she’d like to partner with a larger biotechnology company to move past the trial phase.

“It takes about $3 million to $5 million dollars to get to the clinical trial phase, but around $100 million to move past,” she said.

Schroeder rents her lab space from the UA and continues to work in conjunction with the Cancer Biology program.

Schroeder’s research is just one of the program’s projects, and newly appointed Scientific DirectorNathan Ellis is enthusiastic about moving forward with more.

“DNA sequencing has become big in cancer biology,” Ellis said. “By developing personalized medication, we’re able to treat patients with the right drug for the right tumor at the right time.”

Sequencing allows for same-day analysis on a molecular level of each individual patient’s cancer genomes. This makes for a more specific diagnosis and targeted drug treatments to use in conjunction with broader treatments such as surgery, chemotherapy and radiation.

According to Ellis, DNA sequencing has shown promising results over the years as the technology continues to advance.

“Years ago, childhood leukemia had less than a 10 percent survival rate, but now, it’s closer to 90 percent, in part because of sequencing,” he said.

In June, the UA Genetics Core facility received accreditation from the College of American Pathologists, allowing it to expand its services to provide health care in addition to just research.

As an accredited laboratory, the Genetics Core facility can provide clinical testing for physicians and results for clinical trials.

It also means that a doctor can order genetic testing for patients through the facility with the possibility of reimbursement by the patient’s health-care provider.

“This kind of research can have an immediate impact on a patient’s course of treatment,” Ellis said. “We’ll soon be moving to get the sequencing lab involved in clinical trials.”

Although Ellis calls the cancer biology program a work in progress, since the academic year began in August, he’s already implemented changes, with the goal of encouraging the program’s 35 members to interact.

He organized the program’s first research conference and has initiated bi-weekly meetings so that the members can present on the various works in progress and be aware of what others are doing.

“We have researchers with different views and different expertise, who can all benefit from sharing with one another,” Ellis said.

http://tucson.com/news/local/ua-researcher-s-patented-treatment-could-stop-cancer-metastasis/article_fdf00471-9c2f-540b-9d1a-792c9a655c28.html

World War I

The German chemist Fritz Haber was already developing a process for the fixation of nitrogen from air; this process made Germany self-sufficient in explosives and thus no longer dependent on imports of nitrates from Chile…

from the Encyclopedia Britannica

Havelock Ellis

Henry Havelock Ellis, known as Havelock Ellis (2 February 1859 – 8 July 1939), was a British physician, writer, and social reformer who studied human sexuality. He was co-author of the first medical textbook in English on homosexuality in 1897, and also published works on a variety of sexual practices and inclinations, including transgender psychology. He is credited with introducing the notions of narcissism and autoeroticism, later adopted by psychoanalysis. He served as president of the Galton Institute and, like many intellectuals of his era, supported eugenics.[1]

magictransistor:

Shambhala Mandala. The Magic Kingdom. 1700s.
Shambhala or “bde ‘byung” in Tibetan, means “The source of happiness”. The Kingdom of Shambhala takes a central place in the Kalachakra teachings. Not only did the historical Shakyamuni Buddha teach the Kalachakra tantra at the request of King Suchandra of Shambhala, also the teachings are said to be preserved there. It is predicted that a few centuries from now, a spiritual revival of the world will come from Shambhala.
As can be seen on the image above, Shambhala is usually depicted as circular. Divided like a Dharma-Wheel, it spreads out between high mountains and contains many cities. In the center of the hub is the capital Kalapa. Several people, including the ones who brought the Kalachakra teachings into our world, are said to have traveled there, or have had visions of it. One of the visionaries alive these days is Khamtrul Rinpoche.
As His Holiness the Dalai Lama noted during the 1985 Kalachakra initiation in Bodhgaya, Shambhala is not an ordinary country: ”Although those with special affiliation may actually be able to go there through their karmic connection, nevertheless it is not a physical place that we can actually find. We can only say that it is a pure land, a pure land in the human realm. And unless one has the merit and the actual karmic association, one cannot actually arrive there.”

magictransistor:

Shambhala Mandala. The Magic Kingdom. 1700s.

Shambhala or “bde ‘byung” in Tibetan, means “The source of happiness”. The Kingdom of Shambhala takes a central place in the Kalachakra teachings. Not only did the historical Shakyamuni Buddha teach the Kalachakra tantra at the request of King Suchandra of Shambhala, also the teachings are said to be preserved there. It is predicted that a few centuries from now, a spiritual revival of the world will come from Shambhala.

As can be seen on the image above, Shambhala is usually depicted as circular. Divided like a Dharma-Wheel, it spreads out between high mountains and contains many cities. In the center of the hub is the capital Kalapa. Several people, including the ones who brought the Kalachakra teachings into our world, are said to have traveled there, or have had visions of it. One of the visionaries alive these days is Khamtrul Rinpoche.

As His Holiness the Dalai Lama noted during the 1985 Kalachakra initiation in Bodhgaya, Shambhala is not an ordinary country: ”Although those with special affiliation may actually be able to go there through their karmic connection, nevertheless it is not a physical place that we can actually find. We can only say that it is a pure land, a pure land in the human realm. And unless one has the merit and the actual karmic association, one cannot actually arrive there.”

(via superkintaro)


ideasunknown:

This is how the solar system is actually moving as it traverses the galaxy.

ideasunknown:

This is how the solar system is actually moving as it traverses the galaxy.

(via sclr)

(Source: aclevine51, via sclr)